Modeling Long- and Short-Term Temporal Patterns with Deep Neural Networks

Multivariate time series forecasting is an important machine learning problem across many domains, including predictions of solar plant energy output, electricity consumption, and traffic jam situation. Temporal data arise in these real-world applications often involves a mixture of long-term and short-term patterns, for which traditional approaches such as Autoregressive models and Gaussian Process may fail. In this paper, we proposed a novel deep learning framework, namely Long- and Short-term Time-series network (LSTNet), to address this open challenge. LSTNet uses the Convolution Neural Network (CNN) and the Recurrent Neural Network (RNN) to extract short-term local dependency patterns among variables and to discover long-term patterns for time series trends. Furthermore, we leverage traditional autoregressive model to tackle the scale insensitive problem of the neural network model. In our evaluation on real-world data with complex mixtures of repetitive patterns, LSTNet achieved significant performance improvements over that of several state-of-the-art baseline methods. All the data and experiment codes are available online.Comment: Accepted by SIGIR 201

Slope Instability along the northeastern Iberian and Balearic continental margins

This paper gathers the available information on submarine landslides identified in the northeastern Iberian continental margin and presents new data on both already known landslides and new, previously unknown ones. The 2,000 km2, 26 km3 resulting deposit of the BIG’95 debris flow in the Ebro margin; the 4 up to 16 km2, 0.4 km3 Eivissa slides in the Eivissa Channel; the 2 up to 65.6 km2, 1.46 km3 Barcelona slides in the shallow southern Catalan margin; and the western Gulf of Lions debris flow in the deep north Catalan margin are presented. This compilation is completed with several other previously undescribed small-scale mass-wasting deposits together with those observed in the Balearic Promontory. The amount and widespreading of submarine landslide deposits in the northern Iberian margins demonstrate that these margins are not an exception to the common occurence of these kind of structures worldwide, and gives an idea on this phenomena recurrence even in margins considered moderately quiet, in terms of seismicit

Optimización de la determinación por polarografía diferencial de impulsos de ácido ascórbico en fórmulas para lactantes

El objeto del estudio es la selección de las condiciones adecuadas para la preparación de la muestra y las instrumentalespara la determinación de ácido ascórbico en fórmulas de base láctea para lactantes por polarografía diferencial deimpulsos. La bondad del método se estima determinando los parámetros analíticos. Se obtiene un límite de detecciónequivalente a 15 mg de ácido ascórbico por 100 g de fórmula, una respuesta lineal en el intervalo de 15 a 550 mgde ácido ascórbico por 100g de muestra, una precisión interdía del 4,33% y una recuperación del 95%, valores queindican la bondad del método para el fin propuesto

Optimization of a differential pulse polarography determination of ascorbic acid in infant formulas

El objeto del estudio es la selección de las condiciones adecuadas para la preparación de la muestra y las instrumentales para la determinación de ácido ascórbico en fórmulas de base láctea para lactantes por polarografía diferencial de impulsos. La bondad del método se estima determinando los parámetros analíticos. Se obtiene un límite de detección equivalente a 15 mg de ácido ascórbico por 100 g de fórmula, una respuesta lineal en el intervalo de 15 a 550 mg de ácido ascórbico por 100g de muestra, una precisión interdía del 4,33% y una recuperación del 95%, valores que indican la bondad del método para el fin propuesto.The aim of the study was to select the adequate sample treatment and instrumental conditions to measure, by means of differential pulse polarography, ascorbic acid content in milk-based infant formulas. Once selected the quality of the method was estimated through the analytical parameters. A detection limit equivalent to 15 mg of ascorbic acid per 100g formula, a linear response in the range from 15 to 550 mg of ascorbic acid per 100g sample, an intra day precision of 4.33% and an a recovery of 95%, indicated the method was appropriate for achieving the purpose mentioned.Este trabajo forma parte del proyecto financiado por FEDER + ID (Ref. 1FD97-0284)

Bridging topological and functional information in protein interaction networks by short loops profiling

Protein-protein interaction networks (PPINs) have been employed to identify potential novel interconnections between proteins as well as crucial cellular functions. In this study we identify fundamental principles of PPIN topologies by analysing network motifs of short loops, which are small cyclic interactions of between 3 and 6 proteins. We compared 30 PPINs with corresponding randomised null models and examined the occurrence of common biological functions in loops extracted from a cross-validated high-confidence dataset of 622 human protein complexes. We demonstrate that loops are an intrinsic feature of PPINs and that specific cell functions are predominantly performed by loops of different lengths. Topologically, we find that loops are strongly related to the accuracy of PPINs and define a core of interactions with high resilience. The identification of this core and the analysis of loop composition are promising tools to assess PPIN quality and to uncover possible biases from experimental detection methods. More than 96% of loops share at least one biological function, with enrichment of cellular functions related to mRNA metabolic processing and the cell cycle. Our analyses suggest that these motifs can be used in the design of targeted experiments for functional phenotype detection.This research was supported by the Biotechnology and Biological Sciences Research Council (BB/H018409/1 to AP, ACCC and FF, and BB/J016284/1 to NSBT) and by the Leukaemia & Lymphoma Research (to NSBT and FF). SSC is funded by a Leukaemia & Lymphoma Research Gordon Piller PhD Studentship

Deglacial and Holocene changes in Mediterranean Thermohaline Circulation: A joint perspective from Eastern and Western basins

The dominant arid climate conditions over the Mediterranean (Med) control water properties and the formation processes of intermediate and deep water masses. Deep convection cells occur in both the E- and W-Med basins and there are interconnected through the intermediate waters mostly formed in the easternmost area of the Med. Model projections anticipate that the current situation of climate change will led to an overall weakening of this circulation system during the current century. But the natural range of variability in the intensity of individual cells, the drivers and the inter-connection patterns between the cells is not well stablished. During the recent past (las deglaciation and current Holocene) both E- and W-Med had experienced periods of major disruptions in convection. The last organic layer (ORL1) formed in the W-Med during the deglacial period and later the last sapropel (S1) in the E-Med. Both enhanced productivity and weakening in convection are regarded as the causes in the two events but due to different drivers, the deglacial freshening in the case of the ORL1 and the African monsoon flooding for the S1. Here we present U/Mn ratios measured in the foraminifera diagenetic coatings from sediment cores from both E- and W-Med. The nature of this proxy, that provides information of the oxygen water content, allows its application in a wide range of oceanographical/oxygen conditions, a situation that limits other proxies whose carrier is very sensitive to oxygen content. This approach allows us, by the first time, to compare the oxygen evolution of individual basins and at different water depths by means of the same tool. The comparison with other available proxies let us to interpret the drivers of the changes and analyze the evolution of Med deep and intermediate convection along the ORL1 and S1. This new view advocates for a very close link between these two events but with very distinctive response of the individual cells to the dominant forcings

DNA Methylation of the ABO Promoter Underlies Loss of ABO Allelic Expression in a Significant Proportion of Leukemic Patients

Background: Loss of A, B and H antigens from the red blood cells of patients with myeloid malignancies is a frequent occurrence. Previously, we have reported alterations in ABH antigens on the red blood cells of 55% of patients with myeloid malignancies. Methodology/Principal Findings: To determine the underlying molecular mechanisms of this loss, we assessed ABO allelic expression in 21 patients with ABH antigen loss previously identified by flow cytometric analysis as well as an additional 7 patients detected with ABH antigen changes by serology. When assessing ABO mRNA allelic expression, 6/12 (50%) patients with ABH antigen loss detected by flow cytometry and 5/7 (71%) of the patients with ABH antigen loss detected by serology had a corresponding ABO mRNA allelic loss of expression. We examined the ABO locus for copy number and DNA methylation alterations in 21 patients, 11 with loss of expression of one or both ABO alleles, and 10 patients with no detectable allelic loss of ABO mRNA expression. No loss of heterozygosity (LOH) at the ABO locus was observed in these patients. However in 8/11 (73%) patients with loss of ABO allelic expression, the ABO promoter was methylated compared with 2/10 (20%) of patients with no ABO allelic expression loss (P = 0.03). Conclusions/Significance: We have found that loss of ABH antigens in patients with hematological malignancies is associated with a corresponding loss of ABO allelic expression in a significant proportion of patients. Loss of ABO allelic expression was strongly associated with DNA methylation of the ABO promoter.Tina Bianco-Miotto, Damian J. Hussey, Tanya K. Day, Denise S. O'Keefe and Alexander Dobrovi

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA

In eukaryotes, the Cdt1-bound replicative helicase core MCM2-7 is loaded onto DNA by the ORC-Cdc6 ATPase to form a prereplicative complex (pre-RC) with an MCM2-7 double hexamer encircling DNA. Using purified components in the presence of ATP-γS, we have captured in vitro an intermediate in pre-RC assembly that contains a complex between the ORC-Cdc6 and Cdt1-MCM2-7 heteroheptamers called the OCCM. Cryo-EM studies of this 14-subunit complex reveal that the two separate heptameric complexes are engaged extensively, with the ORC-Cdc6 N-terminal AAA+ domains latching onto the C-terminal AAA+ motor domains of the MCM2-7 hexamer. The conformation of ORC-Cdc6 undergoes a concerted change into a right-handed spiral with helical symmetry that is identical to that of the DNA double helix. The resulting ORC-Cdc6 helicase loader shows a notable structural similarity to the replication factor C clamp loader, suggesting a conserved mechanism of action